There can be a cancer treatment soon on the horizon. According to the researchers at the Stanford University School of Medicine, a new developed treatment was tested on mice, which has the potential to wipe out tumors within ten days.
Science Mag reports, An immune-stimulating mixture was directly injected into tumor of the mice, which boosted the immune system of the animal destroying the injected tumor and also all the other tumors in their body.
This is a very important study,” said immunologist Keith Knutson of the Mayo Clinic, who was not part of the research. “It provides a good pretext for going into humans.”
Though the results have been varied and nearly every human they have tested this method on hasn’t worked. However the goal is the same, to boost the immune system. The researchers have tried injecting various concoctions molecules and viruses into the tumor, medical oncologist Ron Levy of Stanford University in Palo Alto, California, worked with colleagues to test the cancer-fighting capabilities of approximately 20 molecules which includes several types of antibodies that activate immune cells.
The experiment on a mice after injecting the cancer vaccine :
SAGIV-BARFI ET AL./SCIENCE TRANSLATIONAL MEDICINE
The researches injected tumors in mice by inserting cancer cells just below the skin of the abdomen in two different locations and after the tumor started growing. The scientists injected the molecules in each of the mouse and the tumors were checked and the response were documented. A pair of molecule with different functions,a type of DNA snippet called CpG which stimulates dendritic cells which help instigate counter-attacks against cancerous cells and an antibody against the immune cell protein OX40 which serves as a throttle of sorts for T-cells—produced the best results. “On their own, they do almost nothing, but the combination is synergistic,” Levy says.
The team reported to Science Translational Medicine, that the injected molecules into the mouse tumor disappeared in less than 10 days, also other non injected tumors in the body of the mouse disappeared in 20days. Levy and his team tested the approach in a mouse prone to breast tumors. Injecting the mixture into one tumor halted the growth of the second, as well as prevented any new breast tumors from growing.
Levy is hopeful that this combination “will be very effective in patients.” He predicts it may work against various types of cancers. It has the potential to eliminate metastases, the secondary tumors that result when cancer spreads.
The researchers have a big question with determining whether or not to approach the work with humans, because most of the rodent cancer therapies don’t translate to humans. Levy and his team have opened a clinical trial to evaluate the safety of their approach and to test its effectiveness in patients with lymphoma, a cancer of the lymphatic system.
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